Dosage Instructions

The recommended dose of AGGRENOX is one capsule given orally twice daily—one in the morning and one in the evening. AGGRENOX capsules should be swallowed whole without chewing.¹⁴

AGGRENOX is not interchangeable with the individual generic components of aspirin and Persantine® Tablets.¹⁴

Alternative Regimen in Case of Intolerable Headaches

In the event of intolerable headaches during the initial treatment, switch to one capsule at bedtime and low-dose aspirin in the morning. Because there are no outcome data with this regimen and headaches become less of a problem as treatment continues, patients should return to the usual regimen as soon as possible, usually within one week.

If your patients can't afford AGGRENOX, our patient assistance program may be able to help. Call 1 800 556 8317.

Important Information About AGGRENOX

AGGRENOX is indicated to reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis.

In clinical trials, the most common adverse event with AGGRENOX was headache (38.2% vs 32.4% with placebo), which was more frequent at the onset of therapy but diminished over time.¹⁰ GI bleeding with AGGRENOX was comparable to aspirin (4.1% vs 3.2%) and intracranial hemorrhage with AGGRENOX was similar to placebo (0.6% vs 0.4%).

AGGRENOX contains aspirin. Patients who consume three or more alcoholic drinks every day should be counseled about the bleeding risks involved with chronic, heavy alcohol use while taking aspirin. Even low doses of aspirin can increase bleeding time, which can adversely affect patients with bleeding disorders. Patients with a history of active peptic ulcer disease should avoid using aspirin, which can cause gastric mucosal irritation and bleeding. AGGRENOX should be avoided in the third trimester of pregnancy.

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